MHC I on the surface of tumor cells is capable of presenting highly specific peptides called neoantigens. Since they are not expressed in normal cells, these peptides are ideal targets for tumor immunotherapy and tumor vaccines. In recent years, immunotherapy based on tumor neoantigens has received significant attention, but the accurate identification of tumor-specific neoantigens from the...

Targeted drug therapy specifically targets specific abnormalities in cancer cells. By preventing these abnormalities from appearing, targeted drug therapy can kill the cancer cells. Targeted therapy drugs are used to treat certain types of brain tumors. Although there are still relatively few approved targeted drugs in brain tumors, as clinical trials continue, more and more targeted drugs are...

In order to obtain the best effect of antibody production, it is necessary to carefully design the antigen polypeptide, and the design should meet a basic condition: during the immunization process, the antigen will neither produce an overly strong immune response, but at the same time produce Antibodies that have binding capacity for the protein of interest. The design of neoantigen peptides...

Small molecule drugs can reach intracellular or extracellular targets of immune cells involved in specific immune pathways, enhance antitumor immunity, or reduce immunosuppression. Brain tumor small molecule drugs also have potential complementary or synergistic effects with existing immunotherapies. Compared to therapeutic antibodies, small molecule drugs have greater penetration into the...

In recent years, with the development of next generation sequencing (NGS) and other technologies, deep sequencing and single cell sequencing technologies have flourished, and the implementation of the Global Tumor Genome Project and the completion of The Cancer Genome Atlas (TCGA) have created favorable conditions for efficient and accurate personalized sequencing of patients. Currently,...

Introduction of TME biomarker analysis services Tumor markers appear along with tumors and are usually increased in amounts of proteins, oncogenes, tumor suppressor genes and their related products in the form of antigens, enzymes, receptors, hormones or metabolites. It is produced and secreted by tumor cells, or is part of the released tumor cell structure. It exists only in tumor cells and is...