Pembrolizumab Immunotherapy Current & Future of Cancer Treatment Pembrolizumab Immunotherapy is an immune checkpoint inhibitor, a form of immunotherapy, designed to help the immune system target and destroy cancer cells. It is a monoclonal antibody that binds to the programmed cell death 1 (PD-1) protein on T cells, preventing cancer cells from evading immune detection. By blocking this interaction, pembrolizumab enables the immune system to attack and eliminate cancer cells effectively. Initially, it gained accelerated approval from the FDA in September 2014 for treating advanced, refractory melanoma. Since then, pembrolizumab has been approved for several other cancer types, with ongoing clinical trials exploring its potential in additional oncologic conditions. This innovative treatment is accessible right here in Pune! Discover the expertise of Dr. Pratik Patil, recognized as the best oncologist in Pune, specializing in immunotherapy, and can guide you through your cancer treatment options. Read this interesting article on how pembrolizumab transforms treatment across various cancer types. The Role of Pembrolizumab Immunotherapy in Cancer Treatment: Biliary Tract Cancer: Pembrolizumab is used in combination with gemcitabine hydrochloride and cisplatin for biliary tract cancer that is either unresectable or has metastasized. This regimen aims to manage the disease when surgical options are no longer viable. Breast Cancer: For triple-negative breast cancer (TNBC), Pembrolizumab is employed in multiple scenarios: Advanced Stage: It is combined with chemotherapy for patients whose tumors express the PD-L1 protein and are either recurrent, unresectable, or metastatic. Early-Stage: It is used with chemotherapy before surgery and continued alone after surgery in patients with high-risk early-stage TNBC, aiming to reduce recurrence. Classic Hodgkin Lymphoma: Pembrolizumab is used: Adults: For cases that are refractory or have relapsed after initial treatments. Children: For relapsed or refractory cases after at least two other treatment lines. Cervical Cancer: Pembrolizumab’s role in cervical cancer includes: Stage III/IVA: Used alongside chemotherapy and radiation therapy for advanced-stage cervical cancer. Recurrent or Metastatic: Combined with chemotherapy, with or without bevacizumab, for cancers that are PD-L1 positive and have either relapsed or metastasized. PD-L1 Positive Refractory Cases: Administered alone for cancers that have worsened during or after chemotherapy. Cutaneous Squamous Cell Carcinoma: For this skin cancer, Pembrolizumab is indicated in patients whose disease has recurred or spread and is not amenable to surgical or radiation therapy. Endometrial Carcinoma: Pembrolizumab is approved for: Combination Therapy: With carboplatin and paclitaxel followed by monotherapy for patients with advanced or recurrent endometrial cancer. Monotherapy: For MSI-H or dMMR cancers that are not curable by surgery or radiation. Lenvatinib Combination: For cancers that are not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), which have progressed after other therapies. Esophageal and Gastroesophageal Junction Cancer: Pembrolizumab is used: Chemotherapy: Combined with platinum-based chemotherapy and fluoropyrimidine for cancers that cannot be treated with surgery or chemoradiation. As Monotherapy: For squamous cell cancers that are PD-L1 positive, following prior systemic therapy. Gastric Cancer: For advanced gastric or gastroesophageal junction adenocarcinoma: HER2 Positive: Pembrolizumab is used with trastuzumab, fluoropyrimidine, and platinum-based chemotherapy. HER2 Negative: Administered with fluoropyrimidine and platinum-based chemotherapy. Hepatocellular Carcinoma: Pembrolizumab is indicated for patients who have progressed on sorafenib, providing an alternative therapeutic approach for advanced liver cancer. Melanoma: Pembrolizumab is applied in: Advanced Cases: For cancers that are unresectable or metastatic. Adjuvant Therapy: In adults and children aged 12 years and older with stage IIB, IIC, or III melanoma, following surgical resection. Merkel Cell Carcinoma: Pembrolizumab is used for Merkel cell carcinoma that has recurred or spread in both adults and children. Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Cancers Pembrolizumab treats: Solid Tumors: In both adults and children with TMB-H solid tumors have progressed after other treatments and are not amenable to other therapies. Colorectal Cancer: Specific focus on cancers with MSI-H or dMMR characteristics. If you want to explore immunotherapy for your cancer treatment, book an appointment today with Dr. Pratik Patil to discuss your options and take the next step toward your health. https://www.pratikpatil.co.in/pembrolizumab-immunotherapy-current-future-of-cancer-treatment/

Cancer Specialist in Pune - Dr. Pratik Patil You’re looking for best cancer specialist in Pune? If Yes, Then you are at the right place. Our cancer specialist in Pune – Dr. Pratik Patil is highly qualified, experienced, and competitive in oncology. They have successfully treated more than 1000 patients with a high success rate. Our cancer specialist doctor in Pune chooses the best treatment from the compressive range of therapies according to the stages of cancer. Our patients are delighted and often refer us to be the best cancer specialist in Pune. Dr. Pratik Patil, diagnoses and treats all types of cancer, including blood cancer, breast cancer, stomach cancer, colorectal cancer, esophageal cancer, oral cancer, ovarian cancer, anemia cancer, Lymphoma, and lung Cancer. He has about 12+ years of experience as a hemat oncologist and medical oncologist. We believe only experienced experts can handle the critical care required for Cancer treatment.  Cancer is a challenging disease. Even one kind of cancer in different stages bears differently in other patients. Each patient requires an evidence-based personalized care plan with a holistic approach. We offer you the best cancer treatment in Pune. He is one of the few cancer specialists who perform therapy to give his patients a smooth & pain-free recovery from cancer.  At our hospitals, we know that Cancer Treatment requires careful consideration of evidence-based options, which can include more than one of the major therapeutic modalities: chemotherapy, targeted therapy, immunotherapy, and hormonal therapy. The cancer specialist in Pune Dr. Pratik Patil and Team members are professionals who truly want to turn your hope into happiness. We are proud that we are behind the smiles of thousands of our patients. We have achieved this through hard work, dedication, and care by our team. We strive to achieve excellence in providing the highest quality of cancer treatment in Pune. Cancer Treatment In Pune - Why Choose Dr. Pratik Patil? Cancer of any stage can be tough and challenging to treat. The best oncologist – Dr. Pratik Patil offers an extensive range of full-fledged Cancer treatment in Pune to diagnose and treat all types of cancer. Dr. Pratik Patil aims in providing ease of accessibility in specialty care and strives in accomplishing expertise with technology in cancer treatment. Dr. Pratik Patil has earned a reputation and he is recognized for being one of the most preferred Oncologists for cancer treatment in Pune.  Dr. Pratik Patil works with driven hopes and positive results of their hard work to treat their patients with the best care. He promises to deliver the best cancer specialist in Pune. Dr. Pratik Patil uses the upgraded and latest technology supported by our professional consultants, to take a positive step towards cancer treatment in Pune. Why Dr. Pratik Patil is Best Cancer specialist in Pune ? Advance tech: Dr Pratik Patil uses the latest medical technologies to treat cancer patients and achieve healthy living across India. 24*7 Availability: Team of Dr Patil provides personalised medical services to patients, from pre-health check up to post treatment 24×7 and 365 days for cancer treatment in Pune. Health Care Solution: Dr. Patil fulfills the organized provision of medical care to individuals by providing world-class cancer treatment in Pune. Advance Knowledge: Dr Pratik Patil has advanced knowledge in prostate cancer, Lung cancer, breast cancer, GI Cancers, haematological malignancies and other solid tumors. Expertise in Oncology: He is practicing for the last 10 years and treated thousands of patients. His expertise in oncology makes him one of the best cancer specialist in Pune. https://www.pratikpatil.co.in/cancer-specialist-in-pune/

Targeted Therapy and Immunotherapy for Gallbladder Cancer As researchers learn more about the changes in cells that cause gallbladder cancer, they’ve developed drugs to target some of these changes. These targeted drugs work differently from standard chemotherapy (chemo) drugs. They sometimes work when standard chemo drugs don’t, and they often have different side effects. FGFR2 inhibitors: FGFRs (fibroblast growth factor receptors) are proteins on cells that help them grow and divide normally. A small number of people with gallbladder cancer have changes in the genes that make FGFRs, which result in abnormal FGFR proteins that cause cells to grow out of control and turn into cancer. Pemigatinib (Pemazyre) and futibatinib (Lytgobi) are FGFR2 inhibitors. They block the abnormal FGFR2 protein in gallbladder cancer cells and keep them from growing and spreading to other places. These drugs can be used to treat some advanced gallbladder cancers that cannot be removed by surgery or have spread to distant areas after at least one previous chemotherapy treatment. For these drugs to work, your cancer must have an abnormal FGFR2 gene, so your cancer will be tested before starting any of these drugs. These medicines are taken by mouth as tablets, typically once a day. IDH1 inhibitor: In some people with gallbladder cancer, the cancer cells have a change (mutation) in the IDH1 gene, which normally helps cells make the IDH1 protein. Mutations in this gene can lead to an abnormal IDH1 protein, which can stop cells from maturing the way they normally would. Ivosidenib (Tibsovo) is an IDH1 inhibitor. It blocks the abnormal IDH1 protein, which seems to help the cancer cells mature into more normal cells. This drug can be used in people with advanced, previously treated gallbladder cancer, if the cancer cells are found to have an IDH1 mutation. Your doctor can test your cancer cells to see if they have an IDH1 mutation. This drug is taken by mouth, once a day. Less common but more serious side effects can include changes in heart rhythm, pneumonia, and jaundice (yellowing of the eyes and skin). NTRK inhibitor: A very small number of gallbladder cancers have changes in one of the NTRK genes, called NTRK gene fusions. Cells with these gene changes make abnormal TRK proteins, which can lead to abnormal cell growth and cancer. Larotrectinib (Vitrakyi) or entrectinib (Rozlytrek) are NTRK inhibitors. TRK inhibitors target and disable the proteins made by the NTRK genes. This drug can be used in people with advanced gallbladder cancer, who have not received prior systemic therapy. These drugs are taken as pills, once or twice daily. Possible side effects of NTRK inhibitors: Common side effects can include abnormal liver tests; decreased white blood cell and red blood cells; muscle and joint pain; tiredness; diarrhea or constipation; nausea and vomiting; and stomach pain. Less common but more serious side effects can include mental changes, such as confusion, changes in mood, changes in sleep; liver damage; changes in heart rhythm and/or function; vision changes; harm to a fetus. BRAF inhibitor: In some gallbladder cancers, the cells have changes in the BRAF gene. Cells with these changes make an altered BRAF protein that helps them grow. Some drugs target this and related proteins. A combination of BRAF inhibitor and a MEK inhibitor is often given together to treat advanced cancer with the BRAF V600E mutation. Dabrafenib (Tafinlar) is a BRAF inhibitor. Trametinib (Mekinist) is a MEK inhibitor. This drug combination can be used in people with advanced, previously treated gallbladder cancer, if the cancer cells are found to have an BRAF V600E mutation. These drugs are taken as pills or capsules each day. Possible side effects of BRAF inhibitor: Common side effects can include skin thickening, rash, itching, sensitivity to the sun, headache, fever, joint pain, tiredness, hair loss, nausea, and diarrhea. Less common but more serious side effects can include bleeding, heart rhythm problems, liver or kidney problems, lung problems, severe allergic reactions, severe skin or eye problems, increased blood sugar levels, and squamous cell skin cancer. If you need targeted therapy and immunotherapy for gallbladder cancer, please book an appointment with our cancer specialist in Pune, Dr. Pratik Patil. https://www.pratikpatil.co.in/targeted-therapy-and-immunotherapy-for-gallbladder-cancer/

Esophageal Cancer Specialist in Pune - Dr Pratik Patil Are you suffering from the swallowing problems? or you are diagnosed with the esophageal cancer? or ealry stage Esophageal Cancer? and looking for specialists who can help in esophageal cancer treatment in Pune? or you need second opinion on esophageal cancer treatment optionts? Then don’t worry, You’re at the right Place. Dr Pratik Patil is one of the best esophageal cancer specialists in Pune in which he has expertise in managing all stages esophageal cancer with using advanced technology. He has been practicing for more than 12 years and treated thousands of cancer patients and 50+ esophageal cancer patients helps to manage the disease. He is currently working as a Consultant Medical oncologist & Hematologist at the Jupiter Hospital and Healthbay Clinic, Baner, Pune. He has special interests in Immunotherapy, Chemotherapy, Thoracic Oncology, targeted therapy, and pathology & biology of cancers. Dr. Pratik Patil Completed a Thoracic Oncology fellowship at The University of Michigan 500 S. State Street, Ann Arbor, MI 48109 USA and He received a Gold Medal for a Paper presentation at the International Conference On Medical and Biosciences, Bangkok, Thailand 2017. His expertise in Esophageal cancer treatment and his experience in Thoracic Oncology make him one of the best esophageal cancer specialists in Baner, Pune. On this page, He explains all about esophageal cancer and its available treatment options. If you or you’re loved ones are diagnosed with esophageal cancer then read the below information. If you have any questions or treatments you can consult Dr. Pratik Patil What is Esophageal cancer? Esophageal cancer alternately appertained to as esophagus cancer, is a type of malice that arises within the esophagus — a tubular, muscular organ connecting the throat to the stomach. This vital structure plays a central part in easing the movement of ingested food and liquids from the mouth to the stomach, where the digestive process begins. The esophagus is composed of colorful layers, and when cancer develops, it generally initiates in the inmost subcaste and has the implicit to progress to deeper layers. The complaint is characterized by the unbridled growth of cells in the esophageal apkins, leading to the conformation of excrescences that may stymie the organ’s normal function. https://www.pratikpatil.co.in/esophageal-cancer-treatment-in-pune/

Anemia Treatment in Pune Are you feeling weak? or your doctor diagnosed you as an anemia patient and you’re the best doctor for Anemia treatment in Baner, Pune? Dr. Pratik Patil is a Clinical Hematologist in Pune having expertise in Managing various blood disroders and blood cancers. In the Pune region, most of the people (especially Women) are suffering from blood disorders the highest percentage of Anemia disease. Without proper treatment, anemia can lead to severe health complications Hence Dr. Pratik Patil provides a comprehensive and personalized treatment plan for the individuals to treat different types of anemia at Jupiter Hospital and Healthbay Clinic in Baner, Pune. If you or a loved one are experiencing symptoms of anemia and looking for expert care then you can visit an experienced hematologist at Baner, Pune. Dr. Pratik Patil offers comprehensive anemia treatment in Pune, utilizing advanced medical practices and a patient-focused approach to ensure the best outcomes. On this Page, Dr. Pratik Patil explains about anemia & its treatment options. Anemia Treatment in Pune - Dr. Pratik Patil What is anemia? Anemia is a medical condition characterized by a defect in red blood cells or hemoglobin, which is essential for carrying oxygen from the lungs to the body’s tissues. This deficiency can result from various aspects such as nutritional deficiencies, chronic diseases, or genetic disorders. As a consequence, individuals with anemia often experience fatigue and weakness due to inadequate oxygen supply to their cells. Understanding anemia is crucial for timely diagnosis and appropriate treatment to restore normal red blood cell levels and improve overall health. https://www.pratikpatil.co.in/anemia-treatment-in-pune/